Lam DW, LeRoith D. The worldwide diabetes epidemic. Curr Opin Endocrinol Diabetes Obes. 2012;19:93–6.
Unnikrishnan R, Pradeepa R, Joshi SR, Mohan V. Type 2 Diabetes: Demystifying the Global Epidemic. Diabetes. 2017;66:1432–42.
Praet SF, van Loon LJ. Exercise: the brittle cornerstone of type 2 diabetes treatment. Diabetologia. 2008;51:398–401.
Pedersen BK, Saltin B. Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseases. Scand J Med Sci Sports. 2015;25:1–72.
Boule NG, Weisnagel SJ, Lakka TA, Tremblay A, Bergman RN, Rankinen T, et al. Effects of exercise training on glucose homeostasis: the HERITAGE Family Study. Diabetes Care. 2005;28:108–14.
Hawley JA, Lessard SJ. Exercise training-induced improvements in insulin action. Acta Physiol (Oxf). 2008;192:127–35.
Egan B, Zierath JR. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab. 2013;17:162–84.
Hoffmann C, Weigert C. Skeletal Muscle as an Endocrine Organ: The Role of Myokines in Exercise Adaptations. Cold Spring Harb Perspect Med. 2017;7:a029793.
Richter EA, Hargreaves M. Exercise, GLUT4, and skeletal muscle glucose uptake. Physiol Rev. 2013;93:993–1017.
Richter EA, Sylow L, Hargreaves M. Interactions between insulin and exercise. Biochem J. 2021;478:3827–46.
Sjoberg KA, Frosig C, Kjobsted R, Sylow L, Kleinert M, Betik AC, et al. Exercise Increases Human Skeletal Muscle Insulin Sensitivity via Coordinated Increases in Microvascular Perfusion and Molecular Signaling. Diabetes. 2017;66:1501–10.
Lundby C, Jacobs RA. Adaptations of skeletal muscle mitochondria to exercise training. Exp Physiol. 2016;101:17–22.
Pillon NJ, Gabriel BM, Dollet L, Smith JAB, Sardon Puig L, Botella J, et al. Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity. Nat Commun. 2020;11:470.
Ibrahim MM. Subcutaneous and visceral adipose tissue: structural and functional differences. Obes Rev. 2010;11:11–8.
Fasshauer M, Bluher M. Adipokines in health and disease. Trends Pharmacol Sci. 2015;36:461–70.
Kahn CR, Wang G, Lee KY. Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome. J Clin Investig. 2019;129:3990–4000.
Unamuno X, Gomez-Ambrosi J, Rodriguez A, Becerril S, Fruhbeck G, Catalan V. Adipokine dysregulation and adipose tissue inflammation in human obesity. Eur J Clin Investig. 2018;48:e12997.
Stallknecht B, Larsen JJ, Mikines KJ, Simonsen L, Bulow J, Galbo H. Effect of training on insulin sensitivity of glucose uptake and lipolysis in human adipose tissue. Am J Physiol Endocrinol Metab. 2000;279:E376–85.
Riis S, Christensen B, Nellemann B, Moller AB, Husted AS, Pedersen SB, et al. Molecular adaptations in human subcutaneous adipose tissue after ten weeks of endurance exercise training in healthy males. J Appl Physiol (1985). 2019;126:569–77.
Bertholdt L, Gudiksen A, Stankiewicz T, Villesen I, Tybirk J, van Hall G, et al. Impact of training state on fasting-induced regulation of adipose tissue metabolism in humans. J Appl Physiol (1985). 2018;124:729–40.
Ronn T, Volkov P, Tornberg A, Elgzyri T, Hansson O, Eriksson KF, et al. Extensive changes in the transcriptional profile of human adipose tissue including genes involved in oxidative phosphorylation after a 6-month exercise intervention. Acta Physiol (Oxf). 2014;211:188–200.
Ruschke K, Fishbein L, Dietrich A, Kloting N, Tonjes A, Oberbach A, et al. Gene expression of PPARgamma and PGC-1alpha in human omental and subcutaneous adipose tissues is related to insulin resistance markers and mediates beneficial effects of physical training. Eur J Endocrinol/Eur Federation Endocr Soc. 2010;162:515–23.
Larsen S, Danielsen JH, Sondergard SD, Sogaard D, Vigelsoe A, Dybboe R, et al. The effect of high-intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue. Scand J Med Sci Sports. 2015;25:e59–69.
Stinkens R, Brouwers B, Jocken JW, Blaak EE, Teunissen-Beekman KF, Hesselink MK, et al. Exercise training-induced effects on the abdominal subcutaneous adipose tissue phenotype in humans with obesity. J Appl Physiol (1985). 2018;125:1585–93.
Dohlmann TL, Hindso M, Dela F, Helge JW, Larsen S. High-intensity interval training changes mitochondrial respiratory capacity differently in adipose tissue and skeletal muscle. Physiol Rep. 2018;6:e13857.
Hoffmann C, Schneeweiss P, Randrianarisoa E, Schnauder G, Kappler L, Machann J, et al. Response of Mitochondrial Respiration in Adipose Tissue and Muscle to 8 Weeks of Endurance Exercise in Obese Subjects. J Clin Endocrinol Metab. 2020;105:dgaa571.
Needham EJ, Hingst JR, Parker BL, Morrison KR, Yang G, Onslev J, et al. Personalized phosphoproteomics identifies functional signaling. Nat Biotechnol. 2022;40:576–84.
Machann J, Thamer C, Schnoedt B, Haap M, Haring HU, Claussen CD, et al. Standardized assessment of whole body adipose tissue topography by MRI. J Magn Reson Imaging. 2005;21:455–62.
RCoreTeam. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2020 2020.
Kessler K, Hornemann S, Petzke KJ, Kemper M, Markova M, Rudovich N, et al. Diurnal distribution of carbohydrates and fat affects substrate oxidation and adipokine secretion in humans. Am J Clin Nutr. 2018;108:1209–19.
Pivovarova O, Jurchott K, Rudovich N, Hornemann S, Ye L, Mockel S, et al. Changes of Dietary Fat and Carbohydrate Content Alter Central and Peripheral Clock in Humans. J Clin Endocrinol Metab. 2015;100:2291–302.
Frayn KN. Fat as a fuel: emerging understanding of the adipose tissue-skeletal muscle axis. Acta Physiol (Oxf). 2010;199:509–18.
Ludzki AC, Schleh MW, Krueger EM, Taylor NM, Ryan BJ, Baldwin TC, et al. Inflammation and metabolism gene sets in subcutaneous abdominal adipose tissue are altered 1 h after exercise in adults with obesity. J Appl Physiol (1985). 2021;131:1380–9.
Kersten S. Role and mechanism of the action of angiopoietin-like protein ANGPTL4 in plasma lipid metabolism. J Lipid Res. 2021;62:100150.
Ameer F, Scandiuzzi L, Hasnain S, Kalbacher H, Zaidi N. De novo lipogenesis in health and disease. Metab: Clin Exp. 2014;63:895–902.
Sanders FW, Griffin JL. De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose. Biol Rev Camb Philos Soc. 2016;91:452–68.
Fabre O, Ingerslev LR, Garde C, Donkin I, Simar D, Barres R. Exercise training alters the genomic response to acute exercise in human adipose tissue. Epigenomics. 2018;10:1033–50.
Dollet L, Zierath JR. Interplay between diet, exercise and the molecular circadian clock in orchestrating metabolic adaptations of adipose tissue. J Physiol. 2019;597:1439–50.
Sato S, Dyar KA, Treebak JT, Jepsen SL, Ehrlich AM, Ashcroft SP, et al. Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis. Cell Metab. 2022;34:329–345.e8.
Tuvia N, Pivovarova-Ramich O, Murahovschi V, Luck S, Grudziecki A, Ost AC, et al. Insulin Directly Regulates the Circadian Clock in Adipose Tissue. Diabetes. 2021;70:1985–99.
Carrasco-Benso MP, Rivero-Gutierrez B, Lopez-Minguez J, Anzola A, Diez-Noguera A, Madrid JA, et al. Human adipose tissue expresses intrinsic circadian rhythm in insulin sensitivity. FASEB J: Off Publ Feder Am Soc Exp Biol. 2016;30:3117–23.
Feneberg R, Lemmer B. Circadian rhythm of glucose uptake in cultures of skeletal muscle cells and adipocytes in Wistar-Kyoto, Wistar, Goto-Kakizaki, and spontaneously hypertensive rats. Chronobiol Int. 2004;21:521–38.
Shostak A, Meyer-Kovac J, Oster H. Circadian regulation of lipid mobilization in white adipose tissues. Diabetes. 2013;62:2195–203.
Dyar KA, Lutter D, Artati A, Ceglia NJ, Liu Y, Armenta D, et al. Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks. Cell. 2018;174:1571–85 e11.
Stenvers DJ, Jongejan A, Atiqi S, Vreijling JP, Limonard EJ, Endert E, et al. Diurnal rhythms in the white adipose tissue transcriptome are disturbed in obese individuals with type 2 diabetes compared with lean control individuals. Diabetologia. 2019;62:704–16.
Wilms B, Leineweber EM, Molle M, Chamorro R, Pommerenke C, Salinas-Riester G, et al. Sleep Loss Disrupts Morning-to-Evening Differences in Human White Adipose Tissue Transcriptome. J Clin Endocrinol Metab. 2019;104:1687–96.
Pivovarova O, Gogebakan O, Sucher S, Groth J, Murahovschi V, Kessler K, et al. Regulation of the clock gene expression in human adipose tissue by weight loss. Int J Obes (Lond). 2016;40:899–906.
Granata C, Jamnick NA, Bishop DJ. Training-Induced Changes in Mitochondrial Content and Respiratory Function in Human Skeletal Muscle. Sports Med. 2018;48:1809–28.
Stanford KI, Middelbeek RJ, Goodyear LJ. Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations. Diabetes. 2015;64:2361–8.
Whitehead A, Krause FN, Moran A, MacCannell ADV, Scragg JL, McNally BD, et al. Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis. Nat Commun. 2021;12:1905.
Kirk B, Feehan J, Lombardi G, Duque G. Muscle, Bone, and Fat Crosstalk: the Biological Role of Myokines, Osteokines, and Adipokines. Curr Osteoporosis Rep. 2020;18:388–400.
Tsiloulis T, Carey AL, Bayliss J, Canny B, Meex RCR, Watt MJ. No evidence of white adipocyte browning after endurance exercise training in obese men. Int J Obes (Lond). 2018;42:721–7.
McKie GL, Medak KD, Knuth CM, Shamshoum H, Townsend LK, Peppler WT, et al. Housing temperature affects the acute and chronic metabolic adaptations to exercise in mice. J Physiol. 2019;597:4581–600.
Raun SH, Henriquez-Olguin C, Karavaeva I, Ali M, Moller LLV, Kot W, et al. Housing temperature influences exercise training adaptations in mice. Nat Commun. 2020;11:1560.
Lee SD, Priest C, Bjursell M, Gao J, Arneson DV, Ahn IS, et al. IDOL regulates systemic energy balance through control of neuronal VLDLR expression. Nat Metab. 2019;1:1089–100.
Yellaturu CR, Deng X, Cagen LM, Wilcox HG, Park EA, Raghow R, et al. Posttranslational processing of SREBP-1 in rat hepatocytes is regulated by insulin and cAMP. Biochem Biophys Res Commun. 2005;332:174–80.
Hulston CJ, Woods RM, Dewhurst-Trigg R, Parry SA, Gagnon S, Baker L, et al. Resistance exercise stimulates mixed muscle protein synthesis in lean and obese young adults. Physiol Rep. 2018;6:e13799.
Allen JM, Mailing LJ, Niemiro GM, Moore R, Cook MD, White BA, et al. Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans. Med Sci Sports Exer. 2018;50:747–57.
Verboven K, Stinkens R, Hansen D, Wens I, Frederix I, Eijnde BO, et al. Adrenergically and non-adrenergically mediated human adipose tissue lipolysis during acute exercise and exercise training. Clin Sci. 2018;132:1685–98.
Chatzinikolaou A, Fatouros I, Petridou A, Jamurtas A, Avloniti A, Douroudos I, et al. Adipose tissue lipolysis is upregulated in lean and obese men during acute resistance exercise. Diabetes Care. 2008;31:1397–9.